11 The solution contains itraconazole 10 mg/mL solubilized in 40% (v/v) HPCD, which has a ‘cage-like’ structure with a hydrophobic interior but hydrophilic exterior
66 at pH 8
These can be used to enhance the solubility of drugs that are poorly soluble in water as well as lipid media
9) in all investigated solvent compositions
The aim of this work is the enhancement of the hydrosolubility behaviour of a poorly soluble, weakly basic drug, using itraconazole (ITZ) as a case example
Formulating poorly water-soluble drug, itraconazole (ITZ), as dry powder inhaler (DPI) may be more effective for the treatment of invasive pulmonary Aspergillosis than intravenous injection and oral administration
Because 1
Case example: itraconazole Solubility tests indicated that with all formulation approaches, the aqueous solubility of itraconazole formed with hydroxypropyl-β-cyclodextrin (HP-β-CD) or hydroxybutenyl-β Chemsrc provides Itraconazole(CAS#:84625-61-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc
Physical state of poorly water soluble therapeutic molecules loaded into SBA Schematic representation of the effect of excipients in the stability to recrystallize amorphous pure glassy itraconazole when redispersing it in water
64: Miconazole and itraconazole possess adequate membrane permeability, but only slight water solubility, which limits their bioavailability and antifungal effect
7, which makes it a weak base drug
391% in the temperature interval 60–80